1iu1
From Proteopedia
Crystal structure of human gamma1-adaptin ear domain
Overview
The adaptor proteins AP-1 and GGA regulate membrane traffic between the trans-Golgi network (TGN) and endosomes/lysosomes through ARF-regulated membrane association, recognition of sorting signals, and recruitment of clathrin and accessory proteins. The gamma 1-adaptin subunits of AP-1 and GGA possess homologous ear domains involved in the recruitment of accessory proteins, gamma-synergin and Rabaptin-5. The crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain. Structure-based mutational analyses reveal a binding site for the accessory proteins that is composed of conserved basic residues, indicating that the recruitment mechanism in gamma 1-adaptin and GGA is distinct from that in alpha-adaptin.
About this Structure
1IU1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain., Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S, Nat Struct Biol. 2002 Jul;9(7):527-31. PMID:12042876 Page seeded by OCA on Wed May 14 11:35:49 2008
Categories: Homo sapiens | Single protein | Igarashi, N. | Kato, R. | Kawasaki, M. | Matsugaki, N. | Nakayama, K. | Nogi, T. | Shiba, T. | Shiba, Y. | Suzuki, M. | Takatsu, H. | Wakatsuki, S. | Coated pit | Endocytosis
