1jeh
From Proteopedia
CRYSTAL STRUCTURE OF YEAST E3, LIPOAMIDE DEHYDROGENASE
Overview
The crystal structure of eucaryotic lipoamide dehydrogenase from yeast has been determined by an X-ray analysis at 2.7 (partially at 2.4) A resolution. The enzyme has two identical subunits related by a pseudo twofold symmetry. The tertiary structure is similar to those of other procaryotic enzymes. The active site, consisting of FAD, Cys44, and Cys49 from one subunit and His457' from the other subunit, is highly conserved. This enzyme is directly bound to the core protein E2 of the 2-oxoglutarate dehydrogenase complex, whereas it is bound to the pyruvate dehydrogenase complex through a protein X. The calculated electrostatic potential suggests two characteristic regions for binding with these two proteins.
About this Structure
1JEH is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of eucaryotic E3, lipoamide dehydrogenase from yeast., Toyoda T, Suzuki K, Sekiguchi T, Reed LJ, Takenaka A, J Biochem. 1998 Apr;123(4):668-74. PMID:9538259 Page seeded by OCA on Fri May 2 21:07:30 2008
