1lis

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Template:STRUCTURE 1lis

THE CRYSTAL STRUCTURE OF A FERTILIZATION PROTEIN


Overview

Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg. The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic molecule. The surface of the protein exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of aromatic and aliphatic amino acids, and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action.

About this Structure

1LIS is a Single protein structure of sequence from Haliotis rufescens. Full crystallographic information is available from OCA.

Reference

The crystal structure of lysin, a fertilization protein., Shaw A, McRee DE, Vacquier VD, Stout CD, Science. 1993 Dec 17;262(5141):1864-7. PMID:8266073 Page seeded by OCA on Fri May 2 23:57:47 2008

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