1mh1
From Proteopedia
SMALL G-PROTEIN
Contents |
Overview
The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.
Disease
Known disease associated with this structure: Night blindness, congenital stationery, rhodopsin-related OMIM:[180380], Retinitis pigmentosa, autosomal recessive OMIM:[180380], Retinitis pigmentosa-4, autosomal dominant OMIM:[180380]
About this Structure
1MH1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue., Hirshberg M, Stockley RW, Dodson G, Webb MR, Nat Struct Biol. 1997 Feb;4(2):147-52. PMID:9033596 Page seeded by OCA on Wed Apr 30 13:34:28 2008
