1y54

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Image:1y54.gif

Template:STRUCTURE 1y54

Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715


Overview

BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial beta-lactamases. The crystal structure of Enterobacter cloacae 908R class C beta-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C beta-lactamase.

About this Structure

1Y54 is a Single protein structure of sequence from Enterobacter cloacae. Full crystallographic information is available from OCA.

Reference

Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies., Michaux C, Charlier P, Frere JM, Wouters J, J Am Chem Soc. 2005 Mar 16;127(10):3262-3. PMID:15755127 Page seeded by OCA on Sat May 3 15:53:23 2008

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