1z0r
From Proteopedia
Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB
Overview
New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N-terminal, DNA-binding domain of the transition state regulator AbrB. The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. It has a detectable sequence similarity to both MazE and MraZ thus providing an evolutionary link between the two proteins. The putative DNA-binding site of AbrB is found on the same face as the DNA-binding site of MazE and appears similar, both in structure and sequence, to the exposed conserved region of MraZ. This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily.
About this Structure
1Z0R is a Single protein structure of sequence from Bacillus subtilis. This structure supersedes the now removed PDB entry 1ekt. Full crystallographic information is available from OCA.
Reference
Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins., Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG, FEBS Lett. 2005 Oct 24;579(25):5669-74. Epub 2005 Oct 4. PMID:16223496 Page seeded by OCA on Sat May 3 17:02:47 2008
