2gvf

From Proteopedia

Revision as of 02:35, 4 May 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2gvf.gif

Template:STRUCTURE 2gvf

HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021


Overview

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.

About this Structure

2GVF is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease., Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V, Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. Epub 2006 May 30. PMID:16730985 Page seeded by OCA on Sun May 4 05:35:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gvf"
Personal tools