2gtk
From Proteopedia
Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists
Overview
In the quest for novel PPARalpha/gamma co-agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we have used a structure-based design approach to identify propionic acids with a 1,5-disubstituted indole scaffold as potent PPARalpha/gamma activators. Compounds 13, 24, and 28 are examples of submicromolar dual agonists with different alpha/gamma EC50 ratios that are selective against the delta-isoform. Analysis of the X-ray complex structure of PPARgamma with the indole propionic acid 13 provides a rationalization for some of the observed SAR.
About this Structure
2GTK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists., Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Marki HP, Meyer M, Mohr P, Bioorg Med Chem Lett. 2006 Aug 1;16(15):4016-20. Epub 2006 Jun 5. PMID:16737814 Page seeded by OCA on Sun May 4 05:31:08 2008
Categories: Homo sapiens | Protein complex | Benz, J. | Binggeli, A. | Grether, U. | Hilpert, H. | Humm, R. | Kuhn, B. | Maerki, H P. | Meyer, M. | Mohr, P. | Nuclear receptor
