2ix7
From Proteopedia
STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V
Overview
A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (IQxxxR), whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the motif (GxxxR). Variable residues in the IQ motif play a critical role in determining the precise structure of the bound CaM, such that even the consensus residues of different motifs show unique interactions with CaM. This complex serves as a model for the lever arm region of many classes of unconventional myosins, as well as other IQ motif-containing proteins such as neuromodulin and IQGAPs.
About this Structure
2IX7 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features., Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C, Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:17151196 Page seeded by OCA on Sun May 4 08:01:25 2008
Categories: Mus musculus | Protein complex | Cohen, C. | Gaucher, J F. | Houdusse, A. | Krementsova, E. | Mui, S. | Trybus, K M. | Acetylation | Actin-binding | Atp-binding | Ca2+ regulation | Calcium | Calmodulin | Calmodulin-binding | Coiled coil | Complex | Contractile protein | Iq motif | Metal binding | Methylation | Motor protein | Myosin | Nucleotide-binding | Phosphorylation | Ubl conjugation
