1tf3

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Image:1tf3.gif

Template:STRUCTURE 1tf3

TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES


Overview

The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

About this Structure

1TF3 is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA., Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE, Nat Struct Biol. 1997 Aug;4(8):605-8. PMID:9253405 Page seeded by OCA on Sat May 3 09:52:35 2008

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