3ckp

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Image:3ckp.jpg

Template:STRUCTURE 3ckp

Crystal structure of BACE-1 in complex with inhibitor


Overview

We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2' and combination of SAR display a >100-fold increase in potency with good cellular activity (IC(50)=0.15microM) relative to the previously reported compound 3.

About this Structure

3CKP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives., Park H, Min K, Kwak HS, Koo KD, Lim D, Seo SW, Choi JU, Platt B, Choi DY, Bioorg Med Chem Lett. 2008 May 1;18(9):2900-4. Epub 2008 Apr 8. PMID:18434152 Page seeded by OCA on Wed Jun 4 09:55:20 2008

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