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1uzc

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Revision as of 08:53, 3 May 2008 by OCA (Talk | contribs)
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Template:STRUCTURE 1uzc

THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11


Overview

The FF domain is a 60 amino acid residue phosphopeptide-binding module found in a variety of eukaryotic proteins including the transcription elongation factor CA150, the splicing factor Prp40 and p190RHOGAP. We have determined the structure of an FF domain from HYPA/FBP11. The domain is composed of three alpha helices arranged in an orthogonal bundle with a 3(10) helix in the loop between the second and third alpha helices. The structure differs from those of other phosphopeptide-binding domains and represents a novel phosphopeptide-binding fold.

About this Structure

1UZC is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1h40. Full crystallographic information is available from OCA.

Reference

The structure of an FF domain from human HYPA/FBP11., Allen M, Friedler A, Schon O, Bycroft M, J Mol Biol. 2002 Oct 25;323(3):411-6. PMID:12381297 Page seeded by OCA on Sat May 3 11:53:52 2008

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