2viz
From Proteopedia
HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(2-OXO-1-PYRROLIDINYL)-5-(PROPYLOXY) BENZAMIDE
Overview
Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. Herein, is described the lead generation effort which resulted, with the support of X-ray crystallography, in the discovery of potent inhibitors based on a hydroxy ethylamine (HEA) transition-state mimetic. These inhibitors were capable of lowering amyloid production in a cell-based assay.
About this Structure
2VIZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs)., Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1011-6. Epub 2007 Dec 15. PMID:18171614 Page seeded by OCA on Sun May 4 18:54:18 2008
Categories: Homo sapiens | Memapsin 2 | Single protein | Brien, A O. | Clarke, B. | Demont, E. | Dingwall, C. | Dunsdon, R. | Faller, A. | Hawkins, J. | Hussain, I. | Macpherson, D. | Maile, G. | Matico, R. | Milner, P. | Mosley, J. | Naylor, A. | Redshaw, S. | Riddell, D. | Rowland, P. | Smith, K. | Soleil, V. | Stanway, S. | Stemp, G. | Sweitzer, S. | Theobald, P. | Vesey, D. | Walter, D S. | Ward, J. | Wayne, G. | Alternative splicing | Asp-2 | Aspartyl protease | Bace-1 | Beta-secretase | Beta-site app cleaving enzyme | Glycoprotein | Hydrolase | Memapsin-2 | Membrane | Protease | Transmembrane | Zymogen
