1rzk
From Proteopedia
HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B
Overview
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
About this Structure
1RZK is a Single protein structure of sequence from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267 Page seeded by OCA on Sat May 3 08:06:28 2008
Categories: Homo sapiens | Human immunodeficiency virus 1 | Single protein | Choe, H. | Dimitrov, D S. | Farzan, M. | Hendrickson, W A. | Huang, C C. | Kwong, P D. | Majeed, S. | Moore, M J. | Phogat, S. | Robinson, J. | Sodroski, J. | Venturi, M. | Wyatt, R. | Zhang, M Y. | Antigen-binding fragment of human immunoglobulin 17b | Hiv-1 exterior envelope gp120 from laboratory-adapted isolate | Hxbc2 | Surface t-cell glycoprotein cd4
