2pp4
From Proteopedia
Solution Structure of ETO-TAFH refined in explicit solvent
Overview
The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.
About this Structure
2PP4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription., Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH, Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:17572682 Page seeded by OCA on Sun May 4 13:34:24 2008
