1o9m
From Proteopedia
THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.
Overview
The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.
About this Structure
1O9M is a Single protein structure. Full crystallographic information is available from OCA.
Reference
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685 Page seeded by OCA on Sat May 3 03:33:44 2008
