3fde

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Image:3fde.jpg

Template:STRUCTURE 3fde

Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution

Template:ABSTRACT PUBMED 19077538

About this Structure

3FDE is a 6 chains structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications., Hashimoto H, Horton JR, Zhang X, Cheng X, Epigenetics. 2009 Jan 10;4(1). PMID:19077538

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix., Hashimoto H, Horton JR, Zhang X, Bostick M, Jacobsen SE, Cheng X, Nature. 2008 Oct 9;455(7214):826-9. Epub 2008 Sep 3. PMID:18772888

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