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3dox

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Image:3dox.png

Template:STRUCTURE 3dox

X-ray structure of HIV-1 protease in situ product complex

Template:ABSTRACT PUBMED 18704947

About this Structure

3DOX is a 3 chains structure of sequences from Human immunodeficiency virus type 1 (isolate hxb2 group m subtype b). Full crystallographic information is available from OCA.

Reference

  • Bihani S, Das A, Prashar V, Ferrer JL, Hosur MV. X-ray structure of HIV-1 protease in situ product complex. Proteins. 2008 Aug 14. PMID:18704947 doi:10.1002/prot.22174
  • Pillai B, Kannan KK, Hosur MV. 1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR. Proteins. 2001 Apr 1;43(1):57-64. PMID:11170214
  • Kumar M, Prashar V, Mahale S, Hosur MV. Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex. Biochem J. 2005 Jul 15;389(Pt 2):365-71. PMID:15794743 doi:10.1042/BJ20041804
  • Pillai B, Kannan KK, Bhat SV, Hosur MV. Rapid screening for HIV-1 protease inhibitor leads through X-ray diffraction. Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):594-6. Epub 2004, Feb 25. PMID:14993705 doi:10.1107/S0907444903029676
  • Das A, Prashar V, Mahale S, Serre L, Ferrer JL, Hosur MV. Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18464-9. Epub 2006 Nov 20. PMID:17116869

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