2e9w

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Template:STRUCTURE 2e9w

Contents

Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)

Template:ABSTRACT PUBMED 17662946

Disease

Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[164920], Germ cell tumors OMIM:[164920], Leukemia, acute myeloid OMIM:[164920], Mast cell leukemia OMIM:[164920], Mastocytosis with associated hematologic disorder OMIM:[164920], Piebaldism OMIM:[164920], Skin/hair/eye pigmentation 7, blond/brown hair OMIM:[184745]

About this Structure

2E9W is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor., Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J, Cell. 2007 Jul 27;130(2):323-34. PMID:17662946

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