1o46

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Template:STRUCTURE 1o46

Contents

CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.

Template:ABSTRACT PUBMED 14613321

Disease

Known disease associated with this structure: Colon cancer, advanced OMIM:[190090]

About this Structure

1O46 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors., Lange G, Lesuisse D, Deprez P, Schoot B, Loenze P, Benard D, Marquette JP, Broto P, Sarubbi E, Mandine E, J Med Chem. 2003 Nov 20;46(24):5184-95. PMID:14613321

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