3dxc

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spinqualitylabelsall models PDB ID 3dxc Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3dxc, resolution 2.10Å ()
Gene:	APBB1, FE65, RIR (Homo sapiens), APP, A4, AD1 (Homo sapiens)
Related:	3dxd, 3dxe
Structural annotation: Resources: InterPro : Ipr001202, Ipr006020, Ipr011993, Ipr002223, Ipr008154, Ipr008155, Ipr011178, Ipr013803, Ipr015849 Pfam : PF00640 UniProt : O00213, P05067
Functional annotation: Cellular component: nucleus lamellipodium synapse growth cone extracellular region integral to membrane integral to plasma membrane platelet alpha granule lumen coated pit cell surface membrane Biological process: signal transduction regulation of transcription negative regulation of cell growth axonogenesis cell cycle arrest negative regulation of thymidylate synthase biosynthetic process negative regulation of S phase of mitotic cell cycle cell adhesion apoptosis endocytosis cellular copper ion homeostasis Notch signaling pathway neuromuscular process Molecular function: beta-amyloid binding transcription factor binding protein binding heparin binding endopeptidase inhibitor activity metal ion binding binding identical protein binding zinc ion binding copper ion binding acetylcholine receptor binding iron ion binding serine-type endopeptidase inhibitor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2

Template:ABSTRACT PUBMED 18833287

About this Structure

3DXC is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2., Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K, EMBO Rep. 2008 Nov;9(11):1134-40. Epub 2008 Oct 3. PMID:18833287

Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain., Radzimanowski J, Beyreuther K, Sinning I, Wild K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):409-12. Epub 2008 Apr 24. PMID:18453713

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