2hr6

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Template:STRUCTURE 2hr6

Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese

Template:ABSTRACT PUBMED 17932923

About this Structure

2HR6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site., Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG, Proteins. 2008 Apr;71(1):308-19. PMID:17932923

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase., Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG, J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312

Atomic resolution structure of Escherichia coli dUTPase determined ab initio., Gonzalez A, Larsson G, Persson R, Cedergren-Zeppezauer E, Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):767-74. Epub 2001, May 25. PMID:11375495

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