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GLYCOGEN SYNTHASE KINASE 3 BETA

    Glycogen Synthase Kinase 3 Beta has 
in the two opposite quadrants and alpha helices in the other two opposite quadrants.  There are also two active sites that can be seen here: 
                                       

spinqualitylabelsall models PDB ID 1h8f Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1h8f, resolution 2.80Å ()
Ligands:
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Structural annotation: Resources: CATH : 1H8Fa02, 1H8Fa01, 1H8Fb02, 1H8Fb01 InterPro : Ipr011009, Ipr000719, Ipr008271, Ipr002290 Pfam : PF00069 SCOP : d1h8fa_, d1h8fb_ UniProt : P49841
Functional annotation: Cellular component: cytoplasm nucleus beta-catenin destruction complex Biological process: positive regulation of protein export from nucleus peptidyl-serine phosphorylation Wnt receptor signaling pathway through beta-catenin ER overload response Wnt receptor signaling pathway negative regulation of apoptosis protein amino acid phosphorylation intracellular signaling cascade glycogen metabolic process Molecular function: nucleotide binding ATP binding transferase activity p53 binding NF-kappaB binding kinase activity protein serine/threonine kinase activity protein kinase activity protein binding glycogen synthase kinase 3 activity
Evolutionary conservation: Toggle Conservation Colors: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml