User:Karl E. Zahn/Sandbox RB69 1/domain-structure

From Proteopedia

DNA polymerases (pols) are a specialized class of transferase enzymes that catalyze template directed extension of a primed DNA. The family B DNA pol encoded in the genome of the bacteriophage RB69 represents such an enzyme that shares significant homology with the human primase associated pol α, the human replicative pols δ and ε, and the human repair pol ζ. The relative ease with which one can induce RB69 pol to form diffraction quality crystals in complex with DNA, in addition to its homology shared with important human enzymes, has allowed RB69 pol to serve as an extremely useful structural tool and model enzyme.

The first crystal structure of RB69 pol revealed the domain topology characteristic of family B pols: five domainsencodes five domains whose overall spatial arrangement is often likened to that a right hand