2ipj

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Image:2ipj.png

Template:STRUCTURE 2ipj

Contents

Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone

Template:ABSTRACT PUBMED 17442338

Disease

Known disease associated with this structure: Obesity, hyperphagia, and developmental delay OMIM:[600450]

About this Structure

2IPJ is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Faucher F, Cantin L, Pereira de Jesus-Tran K, Lemieux M, Luu-The V, Labrie F, Breton R. Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J Mol Biol. 2007 Jun 1;369(2):525-40. Epub 2007 Mar 27. PMID:17442338 doi:10.1016/j.jmb.2007.03.058

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