X-ray crystallography

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Flow chart showing the major steps in X-ray protein crystallography. (Image from Wikimedia courtesy Thomas Splettstoesser.

About 85% of the models (entries) in the World Wide Protein Data Bank were determined by X-ray crystallography. Protein crystallography remains very difficult, despite many recent advances. For every protein sequence targeted for X-ray crystallography, about one in twenty is solved successfully[1][2].

Notes & References

  1. Success Rates in Protein Crystallography
  2. [proteinexplorer.org/gpsi/xsuccess.htm Structural Genomics Progress Chart]

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Eric Martz, Wayne Decatur, David Canner

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