User:Tilman Schirmer/Sandbox 201
From Proteopedia
PleD
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Intro
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from Caulobacter crescentus is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain,
a Rec-like () adaptor domain,
and a C-terminal domain that confers the catalytic acitvity.
The GGDEF domain is named after the highly conserved (in PleD it is GGEEF) that locates to a β-hairpin.
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The motif is part of the as identified in the struture of the PleD - cene name='User:Tilman_Schirmer/Sandbox_201/Substrate_binding_ctp-a-s_mg/3'>GTP-α-S complex/Mg++</scene>.
Allosteric product binding site
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C-di-GMP
Primary inhibition site (Ip)
Secondary inhibition site (Is)
Primary and secondary inhibition sites
Two conformations
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Non-activated conformation
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: , ,
Activated conformation
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