User:Tilman Schirmer/Sandbox 200

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Cyclic di-GMP signaling

Contents 1 Intro 2 Diguanylate cyclases 2.1 PleD 2.1.1 PleD catalysis 2.1.2 PleD activation 2.1.3 PleD allosteric product inhibition 3 C-di-GMP specific phosphodiesterases 4 C-di-GMP receptors

Intro

Diguanylate cyclases

The condensation reaction 2 GTP -> c-di-GMP + 2 PPi is catalyzed by GGDEF domains that typically occur in combination with sensory or regulator domains. The structures of two diguanylate cyclases have been determined, both being response regulators with a response regulator receiver (Rec) and a GGDEF output (effector) domain. Response regulators are activated through phosphorylation of a conserved aspartate by cognate histidine kinases.

PleD

PleD catalysis

PleD activation

PleD allosteric product inhibition

C-di-GMP specific phosphodiesterases

C-di-GMP receptors