User:Tilman Schirmer/Sandbox 200

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Cyclic di-GMP signaling

Contents 1 Intro 2 Diguanylate cyclases 2.1 PleD 2.1.1 PleD catalysis 2.1.2 PleD activation 2.1.3 PleD allosteric product inhibition 3 C-di-GMP specific phosphodiesterases 4 C-di-GMP receptors

Intro

Diguanylate cyclases

The condensation reaction 2 GTP -> c-di-GMP + 2 PPi is catalyzed by GGDEF domains that typically occur in combination with sensory or regulator domains. The structures of two diguanylate cyclases (PleD and WspR) have been determined, both being response regulators with a response regulator receiver (Rec) and a GGDEF output (effector) domain. Response regulators are activated through phosphorylation of a conserved aspartate by cognate histidine kinases.

PleD

PleD catalysis

PleD activation

PleD allosteric product inhibition

C-di-GMP specific phosphodiesterases

C-di-GMP receptors