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The drug oseltamivir (Tamiflu®) inhibits swine flu neuraminidase "N1", a component necessary for virus spread. The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase. The most common mutation in N1 that makes flu resistant to oseltamivir is H274Y. The mutant tyrosine prevents oseltamivir from fitting, but still allows zanamivir (Relenza®) to bind.

PDB: 3ckz, resolution 1.9 Å
DRAG TO ROTATE.

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Eric Martz, Eran Hodis