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Proposed Article Title: Knots in Proteins

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A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation. A dramatic example, discovered in 2000, is illustrated here.

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Eric Martz, Eran Hodis

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