1al3
From Proteopedia
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COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES
Overview
BACKGROUND: CysB is a tetrameric protein of identical subunits (M(r) =, 36,000) which controls the expression of genes associated with the, biosynthesis of cysteine in bacteria. CysB is both an activator and a, repressor of transcription whose activity is responsive to the inducer, N-acetylserine; thiosulphate and sulphide act as anti-inducers. CysB is a, member of the LysR family of prokaryotic transcriptional regulatory, proteins which share sequence similarities over approximately 280 residues, including a putative helix-turn-helix DNA-binding motif at their N, terminus. The aims of the present study were to explore further the, complex molecular biology and curious ligand binding properties of CysB, and to provide structural insights into the LysR family of proteins., RESULTS: The ... [(full description)]
About this Structure
1AL3 is a [Single protein] structure of sequence from [Klebsiella aerogenes] with SO4 as [ligand]. Structure known Active Site: SUL. Full crystallographic information is available from [OCA].
Reference
The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement., Tyrrell R, Verschueren KH, Dodson EJ, Murshudov GN, Addy C, Wilkinson AJ, Structure. 1997 Aug 15;5(8):1017-32. PMID:9309218
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