1cq3
From Proteopedia
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STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS
Overview
Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with, high affinity. This viral protein competes with the host cellular, CC-chemokine receptors (CCRs), reducing inflammation and interfering with, the host immune response. Such proteins or derivatives may have, therapeutic uses as anti-inflammatory agents. We have determined the, crystal structure to 1.85-A resolution of vCCI from cowpox virus, the, prototype of this poxvirus virulence factor. The molecule is a, beta-sandwich of topology not previously described. A patch of conserved, residues on the exposed face of a beta-sheet that is strongly negatively, charged might have a role in binding of CC-chemokines, which are, positively charged.
About this Structure
1CQ3 is a Single protein structure of sequence from Cupixi virus. Full crystallographic information is available from OCA.
Reference
Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930
Page seeded by OCA on Sun Nov 25 01:48:16 2007
