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User:Anat Levit/Sandbox 2
From Proteopedia
Conclusion
The high conservation of the ligand binding pocket of the prokineticin receptors may explain the very similar affinity of the receptors to their cognate ligands. This has also been observed in other subfamilies of GPCRs (such as dopamine, serotonin, histamine and the adrenergic receptors) and may probably explain the difficulty in obtaining potent subtype-selective compounds in pharmaceutical discovery programs.
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