1p9x

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Image:1p9x.gif

1p9x, resolution 3.40Å

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THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC

Overview

The crystal structure of the ketolide telithromycin bound to the, Deinococcus radiodurans large ribosomal subunit shows that telithromycin, blocks the ribosomal exit tunnel and interacts with domains II and V of, the 23S RNA. Comparisons to other clinically relevant macrolides provided, structural insights into its enhanced activity against macrolide-resistant, strains.

About this Structure

1P9X is a Single protein structure of sequence from Deinococcus radiodurans with TEL as ligand. Full crystallographic information is available from OCA.

Reference

Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804

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