3hiz

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Image:3hiz.png

Template:STRUCTURE 3hiz

Contents

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha

Template:ABSTRACT PUBMED 19805105

Disease

Known disease associated with this structure: Breast cancer, somatic OMIM:[171834], Colorectal cancer, somatic OMIM:[171834], Gastric cancer, somatic OMIM:[171834], Hepatocellular carcinoma, somatic OMIM:[171834], Keratosis, seborrheic, somatic OMIM:[171834], Nevus, epidermal OMIM:[171834], Nonsmall cell lung cancer, somatic OMIM:[171834], Ovarian cancer, somatic OMIM:[171834]

About this Structure

3HIZ is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. Epub 2009 Sep 23. PMID:19805105

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