1l3a
From Proteopedia
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Structure of the plant transcriptional regulator PBF-2
Overview
The crystal structure of p24, the single-stranded DNA (ssDNA) binding, subunit of the plant defense transcription factor PBF-2, has been, determined to 2.3 A resolution. p24 is representative of a novel family of, ubiquitous plant-specific proteins that we refer to as the Whirly family, because of their quaternary structure. PBF-2 is composed of four p24, molecules that interact through a helix-loop-helix motif. This interaction, produces a central pore, with beta-strands radiating outwards, resulting, in a whirligig appearance to the quaternary structure. The, noncrystallographic C(4) symmetry arrangement of p24 subunits is novel for, ssDNA binding proteins and may explain the binding specificity of PBF-2., This structural arrangement also supports the role of PBF-2 in binding, melted promoter regions to modulate gene expression.
About this Structure
1L3A is a Single protein structure of sequence from Solanum tuberosum. Full crystallographic information is available from OCA.
Reference
A new family of plant transcription factors displays a novel ssDNA-binding surface., Desveaux D, Allard J, Brisson N, Sygusch J, Nat Struct Biol. 2002 Jul;9(7):512-7. PMID:12080340
Page seeded by OCA on Sun Nov 25 02:25:36 2007
