Cyclin Dependent Kinase-4
From Proteopedia
CDK4: Introduction
Cyclin Dependent Kinase-4 (CDK4) is a protein that is used in the cell cell cycle. The scene that is currently being shown here is when CDK4 is attached to its inhibitor, Cyclin D. CDK4 by itself is just the green protein shown . This page will discuss the role of CDK4 in the cell cycle as well as CDK4's role in cancer.
Role in the Body
Cyclin Dependent Kinase-4 (CDK4) is activated by Cyclin D during the G1 Phase after the G0 Phase that some cells go into as a rest or dormant phase. There are three types of cyclin D: cyclin D1, cyclin D2, and cyclin D3. The CDK4-Cyclin D complexes are essential for entry in G1 phase. During the G1 Phase, a cell undergoes growth before having to divide again. Therefore, it is essential for the cell to undergo this growth in order for it to be big enough to divide.
Role in Cancer
It is known that CDK4 is over expressed in breast cancer. In an experiment by Yu, Qunyan, et al., mice were given cancer and then tested to see if the the CDK4 protein is over expressed. They found that a lack of CDK4 made mice resistant to breast cancer. <Image:B.jpg' size='300' align='right' caption='Shows the first experiment where one group of mice had CDK4 and tumors were created while the other group of mice did not have CDK4 and were resistant to the tumors' /> In another experiment, they
Proteopedia Page Contributors and Editors (what is this?)
Cory Tiedeman, Michal Harel, Joel L. Sussman, Alexander Berchansky, David Canner, Ann Taylor
