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2bge

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Revision as of 06:40, 30 October 2007 by OCA (Talk | contribs)
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Image:2bge.gif

2bge, resolution 1.8Å

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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS

Overview

Using structure-based design, a new class of inhibitors of protein, tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the, 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

About this Structure

2BGE is a [Single protein] structure of sequence from [Homo sapiens] with T2D as [ligand]. Active as [Hydrolase], with EC number [3.1.3.48]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305

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