This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1u55
From Proteopedia
|
Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)
Overview
Soluble guanylate cyclases are nitric oxide-responsive signaling proteins, in which the nitric oxide sensor is a heme-binding domain of unknown, structure that we have termed the heme-NO and oxygen binding (H-NOX), domain. H-NOX domains are also found in bacteria, either as isolated, domains, or are fused through a membrane-spanning region to, methyl-accepting chemotaxis proteins. We have determined the crystal, structure of an oxygen-binding H-NOX domain of one such signaling protein, from the obligate anaerobe Thermoanaerobacter tengcongensis at, 1.77-angstroms resolution, revealing a protein fold unrelated to known, structures. Particularly striking is the structure of the protoporphyrin, IX group, which is distorted from planarity to an extent not seen before, in protein-bound heme groups. Comparison of the structure of the H-NOX, domain in two different crystal forms suggests a mechanism whereby, alteration in the degree of distortion of the heme group is coupled to, changes on the molecular surface of the H-NOX domain and potentially to, changes in intermolecular interactions.
About this Structure
1U55 is a Single protein structure of sequence from Thermoanaerobacter tengcongensis with CL, HEM and OXY as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases., Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J, Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9. Epub 2004 Aug 23. PMID:15326296
Page seeded by OCA on Sun Nov 25 03:19:46 2007
