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1q3i
From Proteopedia
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Crystal Structure of Na,K-ATPase N-domain
Overview
The structure of the N-domain of porcine alpha(2) Na,K-ATPase was, determined crystallographically to 3.2A resolution by isomorphous, heavy-atom replacement using a single mercury derivative. The structure, was finally refined against 2.6A resolution synchrotron data. The domain, forms a seven-stranded antiparallel beta-sheet with two additional, beta-strands forming a hairpin and five alpha-helices. Approximately 75%, of the residues were superimposable with residues from the structure of, Ca-ATPase N-domain, and a structure-based sequence alignment is presented., The positions of key residues are discussed in relation to the pattern of, hydrophobicity, charge and sequence conservation of the molecular surface., The structure of a hexahistidine tag binding to nickel ions is presented.
About this Structure
1Q3I is a Protein complex structure of sequences from Sus scrofa with NI as ligand. Active as Sodium/potassium-exchanging ATPase, with EC number 3.6.3.9 Full crystallographic information is available from OCA.
Reference
The crystallographic structure of Na,K-ATPase N-domain at 2.6A resolution., Hakansson KO, J Mol Biol. 2003 Oct 3;332(5):1175-82. PMID:14499619
Page seeded by OCA on Sun Nov 25 03:30:29 2007
