1hku
From Proteopedia
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CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION
Overview
C-terminal-binding protein/brefeldin A-ADP ribosylated substrate, (CtBP/BARS) plays key roles in development and oncogenesis as a, transcription co-repressor, and in intracellular traffic as a promoter of, Golgi membrane fission. Co-repressor activity is regulated by NAD(H), binding to CtBP/BARS, while membrane fission is associated with its, acyl-CoA-dependent acyltransferase activity. Here, we report the crystal, structures of rat CtBP/BARS in a binary complex with NAD(H), and in a, ternary complex with a PIDLSKK peptide mimicking the consensus motif, (PXDLS) recognized in CtBP/BARS cellular partners. The structural data, show CtBP/BARS in a NAD(H)-bound dimeric form; the peptide binding maps, the recognition site for DNA-binding proteins and histone deacetylases to, an N-terminal ... [(full description)]
About this Structure
1HKU is a [Single protein] structure of sequence from [Rattus norvegicus] with NAD, GOL and FMT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission., Nardini M, Spano S, Cericola C, Pesce A, Massaro A, Millo E, Luini A, Corda D, Bolognesi M, EMBO J. 2003 Jun 16;22(12):3122-30. PMID:12805226
Page seeded by OCA on Tue Oct 30 08:47:07 2007
Categories: Rattus norvegicus | Single protein | Bolognesi, M. | Cericola, C. | Corda, D. | Luini, A. | Massaro, A. | Millo, E. | Nardini, M. | Pesce, A. | Spano , S. | FMT | GOL | NAD | Acyl-coa | Acyltransferase | Brefeldin a | Golgi membrane | Nad | Transcription co-repression
