1u9s
From Proteopedia
|
Crystal structure of the specificity domain of Ribonuclease P of the A-type
Overview
Large RNA molecules, such as ribozymes, fold with well-defined tertiary, structures that are important for their activity. There are many instances, of ribozymes with identical function but differences in their secondary, structures, suggesting alternative tertiary folds. Here, we report a, crystal structure of the 161-nucleotide specificity domain of an A-type, ribonuclease P that differs in secondary and tertiary structure from the, specificity domain of a B-type molecule. Despite the differences, the, cores of the domains have similar three-dimensional structure. Remarkably, the similar geometry of the cores is stabilized by a different set of, interactions involving distinct auxiliary elements.
About this Structure
1U9S is a Single protein structure of sequence from [1] with BA as ligand. Full crystallographic information is available from OCA.
Reference
Basis for structural diversity in homologous RNAs., Krasilnikov AS, Xiao Y, Pan T, Mondragon A, Science. 2004 Oct 1;306(5693):104-7. PMID:15459389
Page seeded by OCA on Sun Nov 25 03:35:20 2007
Categories: Single protein | Krasilnikov, A.S. | Mondragon, A. | Pan, T. | Xiao, Y. | BA | P rna | Pre-trna | Ribonuclease p rna | Ribozyme | Rnase p | S-domain | Specificity domain | Thermus thermophilus | Trna
