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Reverse transcriptase
From Proteopedia
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Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, in company of Hiv protease and Hiv integrase, the most important part of the protein system that this type of viruses use in the process of infecting their target. Reverse Transcriptase is a RNA-dependent DNA Polymerase, that going against the Central Dogma of Molecular Biology, transcribes ssRNA into dsDNA.
Structure
This 2-chain protein has an usual length of 1000 residues (560 in chain A and 440 for B), the third of them involved in alpha helical secondary structure and almost a quarter in beta sheets,
See Also
- Molecule of the Month (09/2002) at RCSB PDB
- List of Reverse Transcriptase articles at Proteopedia and at RCSB PDB
- Reverse Transcriptase at Wikipedia
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Daniel Moyano-Marino, Joel L. Sussman, Alexander Berchansky, David Canner, Amol Kapoor, Jaime Prilusky, Brian Foley, Lynmarie K Thompson, Eric Martz
