3jq6

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Image:3jq6.jpg

Template:STRUCTURE 3jq6

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7-bis(1-methylethyl)pteridine-2,4-diamine (DX1)

Template:ABSTRACT PUBMED 19916554

About this Structure

3JQ6 is a 4 chains structure of sequences from Trypanosoma brucei. Full crystallographic information is available from OCA.

Reference

  • Tulloch LB, Martini VP, Iulek J, Huggan JK, Lee JH, Gibson CL, Smith TK, Suckling CJ, Hunter WN. Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases. J Med Chem. 2009 Nov 16. PMID:19916554 doi:10.1021/jm901059x

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