3h2l

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Image:3h2l.jpg

Template:STRUCTURE 3h2l

Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor

Template:ABSTRACT PUBMED 19818610

About this Structure

3H2L is a 2 chains structure of sequences from Viruses. Full crystallographic information is available from OCA.

Reference

  • Ruebsam F, Murphy DE, Tran CV, Li LS, Zhao J, Dragovich PS, McGuire HM, Xiang AX, Sun Z, Ayida BK, Blazel JK, Kim SH, Zhou Y, Han Q, Kissinger CR, Webber SE, Showalter RE, Shah AM, Tsan M, Patel RA, Thompson PA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Khandurina J, Brooks J, Okamoto E, Kirkovsky L. Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6404-12. Epub 2009 Sep 17. PMID:19818610 doi:10.1016/j.bmcl.2009.09.045

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