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Solution structure of S8-SP11

Overview

Many flowering plants possess a self-incompatibility system to prevent, inbreeding. In Brassica rapa, self/non-self recognition in mating is, established through S-haplotype-specific interactions between stigma, receptors and S-locus protein 11 (SP11, also called S-locus cysteine-rich, protein) that is encoded at the highly polymorphic S-locus. Here we, describe the solution structure of the SP11 protein of the S8-haplotype, (S8-SP11), which specifically binds to the stigma factor of the same, haplotype. It folds into an alpha/beta sandwich structure that resembles, those of plant defensins. Residues important for structural integrity are, highly conserved among the allelic SP11s, suggesting the existence of a, common folding pattern. Structure-based sequence alignment and homology, modeling of allelic SP11 identified a hyper-variable (HV) region, which is, thought to form a loop that bulges out from the body of the protein that, is amenable to solvent exposure. We suggest that the HV region could serve, as a specific binding site for the stigma receptor.

About this Structure

1UGL is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structure of the male determinant factor for Brassica self-incompatibility., Mishima M, Takayama S, Sasaki K, Jee JG, Kojima C, Isogai A, Shirakawa M, J Biol Chem. 2003 Sep 19;278(38):36389-95. Epub 2003 Jun 30. PMID:12835321

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