Human beta two microglobulin
From Proteopedia
Human beta two microglubulin
Huamn β2-Microglobulin (b2m) is the non-covalently bound light chain of the human class I major histocompatibility complex (MHC-I). its function is to ensure proper folding and cell-surface expression of MHC-1. The natural turnover of MHC-I gives rise to the release of b2m into plasmatic fluids at ~0.1 um and to its catabolism in the kidney In case of renal dysfunction, b2m concentration increases up to 60-fold, giving rise to pathogenic accumulation of filamentous structures, displaying the typical properties of amyloid fibrils, principally in the joints and connective tissue.
