1qgt
From Proteopedia
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HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)
Overview
Hepatitis B is a small enveloped DNA virus that poses a major hazard to, human health. The crystal structure of the T = 4 capsid has been solved at, 3.3 A resolution, revealing a largely helical protein fold that is unusual, for icosahedral viruses. The monomer fold is stabilized by a hydrophobic, core that is highly conserved among human viral variants. Association of, two amphipathic alpha-helical hairpins results in formation of a dimer, with a four-helix bundle as the major central feature. The capsid is, assembled from dimers via interactions involving a highly conserved region, near the C terminus of the truncated protein used for crystallization. The, major immunodominant region lies at the tips of the alpha-helical hairpins, that form spikes on the capsid surface.
About this Structure
1QGT is a Single protein structure of sequence from Hepatitis b virus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the human hepatitis B virus capsid., Wynne SA, Crowther RA, Leslie AG, Mol Cell. 1999 Jun;3(6):771-80. PMID:10394365
Page seeded by OCA on Sun Nov 25 04:05:01 2007
