User:Wayne Decatur/SandboxRibosome&Antibiotics
From Proteopedia
Interactions between the Ribosome and Antibiotics
A major class of antibiotics are those that target protein synthesis.
Given the numerous structures of antibiotics complexed with ribosomes and ribosomal subunits now solved and the complexity of the individual subunits and the files derived from each structure, several technical and pedagogical issues are obstacles to people who are not ribosome specialist or structural biologists appreciating the elegance and insight provided by these structures. Towards that end this package of pages feature:
- Consistent representation and color scheme for the ribosomal subunits, elements and ligands enabling easy visualization of a particular antibiotic binds.
- Links to Proteopedia pages covering the essentials of the structures of each subunit and complete ribosome.
- Data optimized for viewing online in Jmol. This includes limiting much of the files to simply alpha carbon and phosphate atoms and, significantly, combining data split split across multiple PDB coordinate files so the entire ribosome structure is visible at once, an issue the RCSB Protein Data Bank has recently attempted to address, as described here.
Additional Literature and Resources
- Tenson T, Mankin A. Antibiotics and the ribosome. Mol Microbiol. 2006 Mar;59(6):1664-77. PMID:16553874 doi:10.1111/j.1365-2958.2006.05063.x
- Auerbach T, Bashan A, Yonath A. Ribosomal antibiotics: structural basis for resistance, synergism and selectivity. Trends Biotechnol. 2004 Nov;22(11):570-6. PMID:15491801 doi:10.1016/j.tibtech.2004.09.006
